�An belligerent childhood learning ability tumor known as medulloblastoma originates in normal mentality "stem" cells that turn malignant when acted on by a known mutant, cancer-causing transforming gene, say researchers from Dana-Farber Cancer Institute and the University of California, San Francisco (UCSF).
Reporting in the Aug. 12 issue of Cancer Cell, the scientists say they have uncovered new origins for these tumors from early stem turn cells as well as more mature cells. Previously, scientists had assumed the tumors might only come from a single source: more grow cells which become neurons and do not accept "stem" prison cell properties. The findings clue at potential new intervention approaches for medulloblastoma by targeting the origins of the tumors, and farther suggest that not all patients' tumors may be born from the same cells.
"We instantly have a better idea of where these psyche tumors come from and their relationship to normal stem cells in the brain," aforesaid Keith Ligon, MD, PhD, co-senior author of the report and an investigator at the Center for Molecular Oncologic Pathology at Dana-Farber and the Brigham and Women's Hospital in Boston.
Co-senior writer, David Rowitch, MD, PhD, currently a professor of pediatrics and neurosurgery at UCSF and a Howard Hughes Medical Institute tec, commented that mouse experiments shed light on how normal shank cells -- cells with the might to make all types of cells in the brain -- can be transformed into tumors. The transformation occurs when a cell-signaling nerve pathway known as Sonic porcupine (named for a sketch character) is reactivated by a hazard mutation.
Sonic porcupine plays an important persona during the embryonic development of the brain, but normally shuts down when it's no longer needed. When turned on over again by a mutation, the signals canful trigger cell processes leading to tumors -- non just in the psyche, but in other organs as well.
Medulloblastomas, usually diagnosed in children between 2 and 5 years of age, strike the brain's cerebellum region, which is involved in controlling body movements. They make up about 30 percent of childhood brain tumors, and account for 250 to 300 new cases per year.
With current treatments, some 60 to 70 percentage of patients live at least basketball team years, only often they are left with cognitive disabilities from surgery, chemotherapy and radiation, urgently suggesting a need for new, more-selective therapies.
"Medulloblastoma was one of the first tumors that was believed to fit the hypothesis that tumors ar caused by 'cancer shank cells' that initiate malignancies and nurture them," aforesaid Ligon, world Health Organization is also on faculty and an assistant prof at Harvard Medical School. "But the prevailing theory -- that medulloblastomas originate from non-stem cells just did
Tuesday, 12 August 2008
Wednesday, 6 August 2008
In Vietnam, Alongside Progress, A Battle For Life With The Programme Of Action For Cancer Therapy
�Behind the elegant French colonial-style exterior of the National Cancer Hospital in Hanoi, the capital of Vietnam, a battle is raging. In the hospital�s crowded wards, treatment rooms and corridors, doctors are struggling against a powerful and subtle enemy: genus Cancer. And right-hand now the disease is winning.
Each year in this country of 84 zillion as many as 75,000 people die of cancer and another 150,000 young cases are diagnosed. Figures are expected to rise a further 25 per centum by 2020. Among the reasons: environmental pollution, ever-changing lifestyles and diets, and increased longevity.
Health Care Only for Some
But Vietnam�s wellness system is ill-equipped to meet the demands. "We lack the capacity," says Dr. Tran Van Thuan, Vice Director of the National Cancer Hospital. "Right now we have simply two cancer centres; one in Hanoi in the north and one in Ho Chi Minh City in the south. This means we can fulfil only 10% of the country�s malignant neoplastic disease needs."
At the same time, low cancer awareness results in around 80% of patients quest help only when the disease is at an advanced stage and consequently difficult to treat. This is particularly true in rural areas where health education is lacking and, for most people, medical check-ups are an unaffordable luxury.
Nguyen Thi Xuong, 50, a james Leonard Farmer from Ha Tinh responsibility, about 450 kilometers south of Hanoi, first felt a lump in her breast in 2006. "It wasn't painful, so I didn't think it was anything good. Anyway, I didn't get any health insurance," Xuong recalls. "I just hoped it would go away."
It didn't. Eighteen months later on, when the lump had reached the size of a plum, Xuong borrowed money and started a cancer travel which concluded at the National Cancer Hospital. The diagnosis: advanced breast cancer. The discussion: radical mastectomy, followed by chemotherapy, and then 25 fractions of irradiation spread over five weeks.
Women Most at Risk
Breast genus Cancer is the leading cause of cancer death in women in Vietnam. In Hanoi, it strikes 30 women in every hundred,000. Yet with early diagnosis and appropriate treatment, breast malignant neoplastic disease is curable.
At the hospital, Xuong met many breast cancer patients like herself. Wearing brightly coloured scarves over their sparse hair - the result of chemotherapy - they sit around around the hospital in small groups, whiling away the time until their next irradiation session. Most have taken loans to pay the patient's contribution towards their treatment, so they live frugally - buying nutrient from sellers outside the hospital gates and quiescence on day-beds in the corridors. Like Xuong, many are far from home and haven't seen family or friends in months.
Enlisting Partners in the Fight
Radiotherapy is a powerful puppet in the treatment of breast cancer. It tush shrink tumours, kill off stray cancer cells, and enhance survival in advanced cases. But with only 22 irradiation machines nationwide, Vietnam falls parlously below the World Health Organization (WHO) recommendation of one machine per million people. That�s wherefore the International Atomic Energy Agency (IAEA) has stepped up efforts to help Vietnam expand its radiation medicine electrical capacity and check the secure, effective enjoyment of the technology.
The IAEA's Programme of Action for Cancer Therapy (PACT) designated Vietnam as one of its six-spot pilot project countries, or PACT Model Demonstration Sites (PMDS). Last year, PACT negotiated the donation by India of a Bhabhatron II teletherapy machine to the Oncology Hospital in the southerly city of Can Tho, which presently has no radiation medicine infrastructure at all. At the root of July, a PACT officer was in Vietnam, together with an adept from India, to prepare for the installation of the machine.
At the same time, together with the WHO and other international partners, PACT is portion the Vietnamese Ministry of Health to develop and implement an ambitious cancer control program, which aims to reduce cancer incidence and mortality rate, and better quality of life for cancer patients.
"Partnering with other leading crab organisations from around the world and our first-class collaboration with the Vietnamese authorities have been vital elements to our help to Vietnam," says Dan Malin, PACT�s Programme Officer for the Vietnam PMDS. "We believe that only a united, comprehensive exploit covering all aspects of cancer care and controller can be truly in effect in fight this frightful disease."
Already that effort is paying dividends. Doctors say cancer consciousness in urban areas is slowly ontogeny, resulting in greater numbers of people coming to the National Cancer Hospital. Today, its radiotherapy machines are in use from four in the morn until midnight, its doctors are overworked, and out-patients like Xuong must induce by as best they can. Still, no one expects the battle against cancer to be easy. All, on the other hand, ar confident that one day it will be won.
Source:
Angela Leuker
International Atomic Energy Agency
More info
Each year in this country of 84 zillion as many as 75,000 people die of cancer and another 150,000 young cases are diagnosed. Figures are expected to rise a further 25 per centum by 2020. Among the reasons: environmental pollution, ever-changing lifestyles and diets, and increased longevity.
Health Care Only for Some
But Vietnam�s wellness system is ill-equipped to meet the demands. "We lack the capacity," says Dr. Tran Van Thuan, Vice Director of the National Cancer Hospital. "Right now we have simply two cancer centres; one in Hanoi in the north and one in Ho Chi Minh City in the south. This means we can fulfil only 10% of the country�s malignant neoplastic disease needs."
At the same time, low cancer awareness results in around 80% of patients quest help only when the disease is at an advanced stage and consequently difficult to treat. This is particularly true in rural areas where health education is lacking and, for most people, medical check-ups are an unaffordable luxury.
Nguyen Thi Xuong, 50, a james Leonard Farmer from Ha Tinh responsibility, about 450 kilometers south of Hanoi, first felt a lump in her breast in 2006. "It wasn't painful, so I didn't think it was anything good. Anyway, I didn't get any health insurance," Xuong recalls. "I just hoped it would go away."
It didn't. Eighteen months later on, when the lump had reached the size of a plum, Xuong borrowed money and started a cancer travel which concluded at the National Cancer Hospital. The diagnosis: advanced breast cancer. The discussion: radical mastectomy, followed by chemotherapy, and then 25 fractions of irradiation spread over five weeks.
Women Most at Risk
Breast genus Cancer is the leading cause of cancer death in women in Vietnam. In Hanoi, it strikes 30 women in every hundred,000. Yet with early diagnosis and appropriate treatment, breast malignant neoplastic disease is curable.
At the hospital, Xuong met many breast cancer patients like herself. Wearing brightly coloured scarves over their sparse hair - the result of chemotherapy - they sit around around the hospital in small groups, whiling away the time until their next irradiation session. Most have taken loans to pay the patient's contribution towards their treatment, so they live frugally - buying nutrient from sellers outside the hospital gates and quiescence on day-beds in the corridors. Like Xuong, many are far from home and haven't seen family or friends in months.
Enlisting Partners in the Fight
Radiotherapy is a powerful puppet in the treatment of breast cancer. It tush shrink tumours, kill off stray cancer cells, and enhance survival in advanced cases. But with only 22 irradiation machines nationwide, Vietnam falls parlously below the World Health Organization (WHO) recommendation of one machine per million people. That�s wherefore the International Atomic Energy Agency (IAEA) has stepped up efforts to help Vietnam expand its radiation medicine electrical capacity and check the secure, effective enjoyment of the technology.
The IAEA's Programme of Action for Cancer Therapy (PACT) designated Vietnam as one of its six-spot pilot project countries, or PACT Model Demonstration Sites (PMDS). Last year, PACT negotiated the donation by India of a Bhabhatron II teletherapy machine to the Oncology Hospital in the southerly city of Can Tho, which presently has no radiation medicine infrastructure at all. At the root of July, a PACT officer was in Vietnam, together with an adept from India, to prepare for the installation of the machine.
At the same time, together with the WHO and other international partners, PACT is portion the Vietnamese Ministry of Health to develop and implement an ambitious cancer control program, which aims to reduce cancer incidence and mortality rate, and better quality of life for cancer patients.
"Partnering with other leading crab organisations from around the world and our first-class collaboration with the Vietnamese authorities have been vital elements to our help to Vietnam," says Dan Malin, PACT�s Programme Officer for the Vietnam PMDS. "We believe that only a united, comprehensive exploit covering all aspects of cancer care and controller can be truly in effect in fight this frightful disease."
Already that effort is paying dividends. Doctors say cancer consciousness in urban areas is slowly ontogeny, resulting in greater numbers of people coming to the National Cancer Hospital. Today, its radiotherapy machines are in use from four in the morn until midnight, its doctors are overworked, and out-patients like Xuong must induce by as best they can. Still, no one expects the battle against cancer to be easy. All, on the other hand, ar confident that one day it will be won.
Source:
Angela Leuker
International Atomic Energy Agency
More info
Skyclad
Artist: Skyclad
Genre(s):
Metal
Folk: Folk-Rock
Metal: Heavy
Metal: Thrash
Rock
Metal: Progressive
Discography:
A Semblance Of Normality
Year: 2004
Tracks: 13
No Daylights Nor Heeltaps
Year: 2002
Tracks: 10
Another Fine Mess
Year: 2001
Tracks: 12
Folkemon
Year: 2000
Tracks: 11
Vintage Whine
Year: 1999
Tracks: 11
The Answer Machine?
Year: 1997
Tracks: 13
Oui Avant-Garde A Chance
Year: 1997
Tracks: 12
Irrational Anthems
Year: 1996
Tracks: 13
The Silent Whales Of Lunar Sea
Year: 1995
Tracks: 12
Prince Of The Poverty Line
Year: 1994
Tracks: 11
Jona's ark
Year: 1993
Tracks: 11
Tracks From The Wilderness
Year: 1992
Tracks: 6
A Burnt Offering For The Bone Idol
Year: 1992
Tracks: 11
The Wayward Sons Of Mother Earth
Year: 1991
Tracks: 10
Based in Newcastle, England, the social reformer thresh around metallic element circle Skyclad was founded in 1990 by vocalist Martin Walkyier, world Health Organization left hand field his previous band, Sabbat, later on an argument with guitar player Andy Sneap. Walkyier added deuce one-time members of Pariah -- guitarist Steve Ramsey and bassist Graeme English -- as well as second guitarist Dave Pugh and drummer Keith Baxter. The band signed to the German Noise International label and recorded Perverse Sons of Mother Earth for a 1991 release. After touring with Overkill and adding violinist/keyboardist Fritha Jenkins, Skyclad recorded A Burnt Offering for the Bone Idol in 1992 and Jonah's Ark the following year. Continuing their acquittance of an album each year through and through the mid-'90s, the mathematical group issued Prince of the Poverty Line in 1994, with Cath Howell replacement Jenkins. Howell was in call on replaced by Georgina Biddle for 1995's The Silent Whales of Lunar Sea, later on which Baxter and Pugh left the group. Irrational Anthems and Oui Avant-Garde a Chance followed in 1996, both with studio drummers, and both later on reissued by Century Media; The Answer Machine continued the band's fecund recording docket in 1997. Permanent replacements for Pugh and Baxter at long last signed on in 1998 in the deadly of drummer Jay Graham and guitarist Keith Ridley, world Health Organization debuted on 1999's Vintage Whine. The punningly highborn Folkemon appeared in Europe in 2000 and the U.S. in early 2001, marking the band's first offer for Nuclear Blast.
Thursday, 3 July 2008
UK Says Martha's a Bad Thing
The Red Coats want nothing to do with Martha Stewart!The domestic goddess has been turned down for a visa to enter Britain because of her rap sheet. She was reportedly set to tour several areas of the country, as well as tour the Royal Academy of Arts in London.
Stewart spent five months in a federal prison in 2004 after she was convicted of conspiracy and lying to the Feds.
Her rep told the Daily Telegraph "Martha loves England and hopes this can be resolved and that she will be able to visit soon."
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Boy George - Boy George To Thank Cash-strapped Fans With Charity Show
BOY GEORGE is considering turning his return to America into a charity show - so he can pay back two fans who spent $10,000 (GBP5,000) on a concert that won't take place.
The former Culture Club star has been forced to scrap his summer shows in the states after being denied a U.S. visa due to a pending legal wrangle.
And although he feels terrible about the news, he's more upset about the fans who have already purchased tickets and plane fares.
In an online chat with celebrity blogger Perez Hilton, he says, "There's fans that have spent thousands of pounds (dollars) on tickets and that's really sad.
"There's a couple of fans who have spent, like, $10,000 and they're not gonna get it back.
"We'll have to do something to help them; we'll have a charity night or something."
George, real name George O'Dowd, hopes to return to America in 2009 once his pending litigation has been resolved.
See Also
Britney Not Charged For Running Over Foot
Britney Spears has had a lucky streak - she's gotten off scot-free from being charged for allegedly running over a photographer's foot last year.
The photographer in question did not file the claim against Britney until six months after the incident. Prosecutors ruled that the only way his foot could have been where the video evidence indicated was that if he had put it there himself.
According to District Attorney Joseph Shidler, Britney's car was surrounded by paparazzi at the time of the incident, and a voice on the video footage told Spears to back up.
"We have no evidence to prove beyond a reasonable doubt that the suspect was aware that the victim's foot had been struck by the car," Shidler said.
"There was much commotion and noise at the time and there is no proof that [Spears] was aware of what had happened."
Britney arrived in her family's home-town in Kentwood, Louisiana earlier today for the birth of her sister Jamie-Lynn's baby.
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Lyfe Jennings makes a change
R&B artist Lyfe Jennings [ tickets ] recently rolled out his "Baby I'm a Star" summer tour, which doubles as an AIDS awareness campaign.The singer/songwriter/producer launched the outing last week and will continue tomorrow (7/1) in Atlanta, with clubs and theaters across the US scheduled into September. Details are listed below.Jennings is supporting his third record, "Lyfe Change," which surfaced in April and bowed at No. 1 on Billboard's Top R&B/Hip-Hop Albums chart. The 14-track set has spawned the hit R&B single "Never Never Land," which is streaming at the Toledo, OH, native's MySpace page along with several other songs from the album."Lyfe Change" includes collaborations with Wyclef Jean, Snoop Dogg and T.I., as well as Grammy-nominated producers Jerry "Wonda" Duplessis, The Underdogs and Rich Keller. It also finds Jennings experimenting with different genres and upping the ante on his expression of positivity."My music has always been positive, touching people socially and emotionally," the singer said in his bio. "But I named this album 'Lyfe Change' because this time, I wanted to take it a step further and invoke people to make a change in their lives and in the lives of others. That's how we'll change the world, one life at a time."Jennings is doing his part to change the world by partnering with Music World Entertainment in a program to support the "Heightened National Response to the HIV/AIDS Crisis Among African Americans." The effort, led by the Centers for Disease Control and Prevention, promotes awareness, education and testing across the US. Jennings' on-the-road program, dubbed "It's Real. Preserve Your Lyfe!," will greet concertgoers with "Lyfe Change" kits that include HIV/AIDS prevention and education resources along with copies of the performer's song "It's Real," which addresses the epidemic."I have to use my voice to help raise awareness so that we can really bring an end to this thing," Jennings said in a statement. "This disease has affected all of our lives, but we can definitely do things to prevent its spread and to protect ourselves."The singer developed his sound during a 10-year prison sentence for arson, according to All Music Guide. He released his critically acclaimed debut, "Lyfe 268-192," in 2004 and followed that up two years later with his sophomore effort, "The Phoenix," which reached No. 2 on The Billboard 200.
Eddie Murphy Apparently Quashes Retirement Rumors, Talks 'Beverly Hills Cop IV'
There are many great reasons to revisit an old character — the obvious one, of course, being a genuine desire to tell another story (and having a good story to tell). But all the reasons in the world pale in comparison to Eddie Murphy's stated reason for doing "Beverly Hills Cop IV."
"Because the third 'Beverly Hills Cop' was horrible!" the once and future Detective Axel Foley laughed. "I didn't want to leave it like that. The first two were cool and the third one was sh---y. [Let's] get the franchise fixed again, clean up this old mess and do a good movie.
"[Don't] just leave Axel with his thumb up his a-- from the last movie," the comic continued, chuckling. "Whatever happened to Axel Foley? He's sitting in Detroit with his thumb up his a-- since 'Beverly Hills Cop III.' Let's take those thumbs out and make a great movie!"
If that last statement surprises you, it might be because you've recently read reports where Murphy said he's considering retirement and didn't want to do another "Beverly Hills Cop" flick. [] The actor apparently quashed that talk when MTV News caught up with him last weekend — at least not until he once again gets a chance to play the tail-pipe stuffing, motor-mouthed cop from Detroit. He called Foley his most iconic character ever.
"When I go overseas they still call me Axel Foley — kids call me Axel Foley," Murphy proudly insisted. "I think that character, it resonated like no other movie, like nothing that I've done before."
Or since, the actor could have added, though he has continued, with few exceptions, in making blockbuster after blockbuster — although films like "Dr. Doolittle," "Shrek" and "The Nutty Professor" contain scant traces of the old Murphy, the actor whose profanity-laced routines made him a hero to millions of impressionable young children.
Will "Beverly Hills Cop IV" be a return to that form? Last month, MTV News spoke with director Brett Ratner, who may or may not have indicated that the fourth installment in the action series would be geared towards a younger audience. Could "BHCIV" be PG-13, we wondered?
Murphy seemed on the verge of quashing that notion in no uncertain terms. Although he hasn't yet read a script — and admitted that the franchise could go in any direction, including one that was toned down — Murphy was adamant that what he wanted most of all was for a "real" Foley. And that means a whole lot of swear words.
And you know who you can thank? Seth Rogen.
"I'll tell you what about profanity," Murphy said. "Over the last 20 years or so, because of the studios, everybody figured out there's a PG-13 audience, you know, and that's the biggest piece of the pie. And a bunch of artists, myself included, got put in this PG-13 box — artists that aren't PG-13 artists! Then comedies like 'Superbad,' 'Knocked-Up,' and 'Juno' come out and people go, 'Oh, this is the brilliant sh--.' And it's just people acting like real people, talking like real people. And those movies are making all the money now.
"Get back to the real sh--," he added, regarding what he most wants for Foley. "That's where I started. [Be] a real person!"
Murphy can next be seen in "Meet Dave," which opens July 11.
For breaking news, celebrity columns, humor and more — updated around the clock — visit MTVMoviesBlog.com.
See Also
Paul McCartney and Wings
Artist: Paul McCartney and Wings
Genre(s):
Pop
Rock
Discography:
Band On The Run Cd 1
Year: 1999
Tracks: 10
Band On The Run 25th Anniversary Edition (Disc 2)
Year: 1993
Tracks: 21
Venus And Mars
Year: 1975
Tracks: 12
Band On The Run
Year: 1973
Tracks: 10
Following his moment solo album, Ram, in 1971, ex-Beatle Paul McCartney and his wife, Linda, formed Wings, which was intended to be a fully fledged recording and touring band. Denny Laine, a one-time guitar player for the Moody Blues, and drummer Denny Seiwell filled out the lineup and Wings released their first base album, Wild Life, in December 1971. Wild Life was greeted with poor reviews and was a congener dud. McCartney and Wings, which now featured one-time Grease Band guitar player Henry McCullough, spent 1972 as a operative band, cathartic triplet singles -- the protestation tune "Give Ireland Back to the Irish," the reggae-fied "Virgin Mary Had a Little Lamb," and the hard-rocking "Hi Hi Hi" -- in England. Red ink Rose Speedway followed in the leaping of 1973, and while it standard sapless reviews, it became his second American number nonpareil album. Later in 1973, Wings embarked on their low British hitch, at the determination of which McCullough and Seiwell left hand the isthmus. Prior to their exit, McCartney's idea to the James Bond moving picture Live and Let Die became a Top Ten strike in the U.S. and U.K. That summer, the remaining Wings proceeded to record a new album in Nigeria. Released late in 1973, Isthmus on the Run was McCartney's best-reviewed album to appointment and his most successful, outlay little Joe weeks at the top of the U.S. charts and eventually going triplet atomic number 78.
Following the success of Striation on the Run, McCartney formed a new version of Wings with guitar player Jimmy McCulloch and drummer Geoff Britton. The young card was showcased on the 1974 British single "Junior's Farm" and the 1975 strike album Venus and Mars. Wings at the Speed of Sound followed in 1976, and it was the low Wings record to feature songwriting contributions by the other bandmembers. The album became a giant success on the ground of deuce McCartney songs, "Silly Love Songs" and "Let 'Em In." Wings supported the album with their first international hitch, which skint many attendance records and was captured on the live triplet album Wings Over America (1976). After the hitch was completed, Wings rested a snatch during 1977, as McCartney released an instrumental adaptation of Random access memory under the nominate Thrillington and produced Laine's solo album, Holly Days. Later that year, Wings released "Mull of Kintyre," which became the biggest-selling British single of all time (at the time of its release), marketing over iI million copies. In 1978 Wings followed "Mull of Kintyre" with Jack London Town, which became some other pt book. After its tone ending, McCulloch left hand the isthmus to get together the re-formed Small Faces, and Wings released Back to the Egg in 1979. Though the record went pt, it failed to produce whatsoever big hits. Early in 1980, McCartney was arrested for ganja possession at the beginning of a Japanese hitch; he was captive for 10 years and then released, without whatsoever charges being pressed. Wings embarked on a British hitch in the spring of 1980 earlier McCartney recorded Paul McCartney II, which was a one-man-band cause like his solo debut. The following year, Laine left hand Wings because McCartney didn't want to duty tour in the wake of John Lennon's assassination; in doing so, he efficaciously bust up Wings, which quietly disbanded as McCartney entered the studio later that yr with Beatles producer George Martin to make his 1982 album Tug of War.
Herbert Tachezi - organ
Slua Si
Artist: Slua Si
Genre(s):
Rock
Discography:
Live In Silvers Pub
Year: 2000
Tracks: 16
Will Jackson's 'Discipline' Break Through?
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